89th Canadian Chemistry Conference Abstracts


Biological and Medicinal Chemistry Division

Sunday AM

BM3CC-Highland 8

Computational Methods in Drug Design (Joint with PT) (joint with PT4)

Organizer(s) - Donald Weaver
Chair(s) - Donald Weaver, Jack Bikker

08:00 00032 Using Molecular Dynamics Simulation for the Treatment of Solvation and Protein Flexibility in Docking Sutherland‡ J.J., Robertson D.H., Erickson J., Vieth M.
08:40 00033 FITTED1.0: A Suite of Programs to Dock Ligands into Flexible and Solvated Macromolecules Moitessier N., Corbeil C.R., Englebienne P.
09:00 00034 An Improved Method For Ligand Receptor Docking: Application to Estrogen Receptor Shadnia H., Ziebell T., Wright J.S.
09:20 00035 A Molecular Dynamics Study of the Effect of the Met129[ Val Mutation on the Prion Protein LaPointe S.M., Boyd R.J., Weaver D.F.
09:40 Coffee Break
10:00 00036 Group Fusion Similarity Searching and Reverse Fingerprint Fragment Scoring Williams‡ C.I.
10:40 00037 GLARE: A Method for Extremely Fast Rough Cut-to-Shape on Immense Virtual Combinatorial Libraries Truchon‡ J.-F., Bayly C.I.
11:20 End of Session


REMINDER
11:25 Montreal Medal Lecture presented by Richard Puddephatt in CC-Port Royal C1

BM5CC-Highland 7

Enzymes: Mechanism, Function and Structure

Organizer(s) - Stephen Bearne
Chair(s) - Stephen Bearne

08:00 00038 Kinetic, Calorimetric, and X-Ray Structural Studies of MosA, a Dihydrodipicolinate Synthase but Apparently not a Methyltransferase Palmer‡ D.R.J., Delbaere L.T.J., Phenix C.P., Tam P.H., Leduc Y., Puttick J., Nienaber K.
08:40 00039 Single Enzyme Molecule Assays of Cell Free Expressed b-Galactosidase Nichols E.R., Craig D.B.
09:00 00040 Transglutaminase Mechanistic Studies Keillor‡ J.W., Chica R., Gravel C., Pelletier J.N
09:40 Coffee Break
10:00 00041 Stabilization of a Cationic Intermediate by AroA (Enolpyruvyl Shikimate 3-Phosphate Synthase) Clark M.E., Berti P.J.
10:20 00042 Probing the pH-Dependence of Ionizable Residues in the Mechanism of Chorismate Mutase from a Bifunctional Enzyme Manioudakis J., Turnbull J.L.
10:40 00043 Chemical and Mechanistic Diversity within the Amidohydrolase Superfamily of Enzymes Raushel‡ F.M.
11:20 End of Session


REMINDER
11:25 Montreal Medal Lecture presented by Richard Puddephatt in CC-Port Royal C1

BM9CC-Mariner 5

Peptide Science (Joint with OR) (joint with OR9)

Organizer(s) - William Lubell
Chair(s) - Robert Ben

09:00 00044 Synthesis of Pharmacophoric Hydroxypyrroloindolinyl-Xaa Dipeptides en route to Amatoxins and Phallotoxins May J.P., Perrin‡ D.M.
09:40 Coffee Break
10:00 00045 Design and Synthesis of Novel b-Peptides as Entry Inhibitors of Hepatitis C Virus Kaur‡ K., Beleid R.
10:20 00046 Cholesterol and the Interaction of Proteins with Membrane Domains Epand‡ R.M.
10:40 00047 Structural Analysis of the GD2 Ganglioside and GD2-Ganglioside Binding Peptides Blankenship J.W., Lubell W.D., Gagnon M., Tong W., Saragovi H.U., Cheung N.-K.V.
11:00 00048 Versatile Fluorescence-Based Characterization and Selection of Genetically Encoded Peptides that Fold Efficiently in Live Cells Cheng Z., Campbell‡ R.E.
11:20 End of Session


REMINDER
11:25 Montreal Medal Lecture presented by Richard Puddephatt in CC-Port Royal C1


Sunday PM

BM3CC-Highland 8

Computational Methods in Drug Design (Joint with PT) (joint with PT4)

Organizer(s) - Donald Weaver
Chair(s) - Donald Weaver, Jack Bikker

13:40 00187 Improving Hit Enrichment in Structure-Based Virtual Screening Using Interfacial Surface and Pharmacophore Filters Cross‡ J.B., Jalaie M., Narasimhan L.S., Domagala M., Bardouniotis E., Sharma V., Fiebig K.
14:20 00188 Practical Application of Integrated Virtual Screening Methods Bikker‡ J.A., Dunbar J.B., Jalaie M., Kirchhoff P., Mack D., Narasimhan L., Shanmugasundaram V.
15:00 Coffee Break
15:20 00189 Computer-Aided Design of Anti-Amyloid Drugs for the Treatment of Alzheimer's Disease Barden‡ C.J., Carter M.D., Weaver D.F.
16:00 00190 Design and 'Virtual' Screening of Potent Peptidic bAmyloid Oligomerization Blocker Ligands Using Computer Aided Drug Design Techniques. Roy S., Rauk A.
16:20 00191 Computational Modelling of Enzymes: The Ability of Uracil Derivatives to Act as Pro-Drugs for b-Amino Acid Antiepileptogenic Agents Tiedje K.E., Weaver D.F.
16:40 00192 Determining Putative Pharmacophores for General Anaesthetics: A Molecular Modelling Study Campagna-Slater V., Weaver D.F.
17:00 End of Session

BM5CC-Highland 7

Enzymes: Mechanism, Function and Structure

Organizer(s) - Stephen Bearne
Chair(s) - Stephen Bearne

13:40 00193 Transition State Analysis of MutY, a DNA Repair Enzyme McCann J.A.B., Berti P.J.
14:20 00194 How do Enzymes Enhance Reaction Rates? Alternative Thermodynamic Strategies Schroeder G.K., Wolfenden‡ R.
15:00 Coffee Break
15:20 00195 Recent Progress in the Study of Inhibition of Fungal Saccharopine Dehydrogenase: Towards Antifungal Agents with a Novel Mode-of-Action Fletcher R.S., Maronne L., Goodfellow V., Shang M., Brown M., Beshara C., Dmitrienko G.I.
15:40 00196 Synthesis of Sialyl-Lactose Analogues for Continuous Assay of Sialidase Activity Indurugalla D., Watson J.N., Bennet A.J.
16:00 00197 Mechanistic Requirements for the Hydrolysis of 2-Thiosialosides Bennet A.J., Narine A.A., Watson J.N.
Bernard Belleau Award Lecture presented by Jik Chin

Introduction of Jik Chin by Peter Guthrie

16:20 00198 Ligand Design: From Artificial Hydrolytic Metalloenzymes to Stereoselective Recognition Chin‡ J.
17:00 End of Session

BM9CC-Highland 10

Peptide Science (Joint with OR) (joint with OR9)

Organizer(s) - William Lubell
Chair(s) - David Perrin

13:40 00199 Self-Assembly of Non-Cyclic Bis-D- and L-tripeptides into Higher Order Tubular Constructs - Design, Synthesis and X-ray Crystal Superstructure Hanessian‡ S., Fettis K., Maris T., Vinci V., Phan Viet M.T.
14:20 00200 Searching for a Common Link: Applications of the "Promiscuous Drug Concept" to Alzheimer's Disease Meier-Stephenson V.C., Weaver D.F
14:40 00201 Genomic Prospecting of the Oceans for Therapeutic Peptides Douglas‡ S.E., Gallant J.G., Patrzykat A.
15:00 Coffee Break
15:20 00202 Synthesis and Properties of Conformationally-Constrained Glycopeptides Schweizer‡ F., Owens N., Zhang K.
15:40 00203 C-Linked Antifreeze Glycoprotein Analogues as Potent Inhibitors of Recrystallization Liu S., Ben‡ R.N.
16:20 End of Session


REMINDER
16:20 R.U. Lemieux Award Lecture presented by André Charette in CC-Port Royal C1


Monday AM

BM5CC-Highland 7

Enzymes: Mechanism, Function and Structure

Organizer(s) - Stephen Bearne
Chair(s) - Stephen Bearne

08:00 00421 Insights of Interfacial Function for the Secreted Phospholipase A2 Family Bahnson‡ B.J.
08:40 00422 Structural Studies of Ni Trafficking Proteins: NikA and HypA Kennedy D.C., Iwig J.S., Chivers P.T., Maroney M.J.
09:00 00423 The Mechanism of ADP-Heptose 6-Epimerase Morrison J.P., Read J.A., Tanner‡ M.E.
09:40 Coffee Break
10:00 00424 Catalytic Functions of the Anthrax Lethal Factor Dabous J.R., Carbone R.X., Siemann S.
10:20 00425 Inhibition by Tyrosine of a Cyclohexadienyl Dehydrogenase from Aquifex aeolicus Bonvin J., Turnbull J.L.
10:40 00426 Identification and Characterization of Recognition Motifs Governing O-GlcNAc Modification Macauley M.S., Chan H.W., Kim Y.-N., Drapala R., Vocadlo D.J.
11:00 00427 Critical Steps in Thiamin-Dependent Decarboxylations - And What Does the Protein Do to Help? Kluger‡ R., Hu Q., Yu D., Ikeda G.
11:40 End of Session

BM9CC-Highland 10

Peptide Science (Joint with OR) (joint with OR9)

Organizer(s) - William Lubell
Chair(s) - William Lubell

08:00 00428 Exploiting Diversity in Chemistry and Biology Space with Integrated Combinatorial Technologies St. Hilaire‡ P.M.
08:40 00429 The Ring of Truth: Do Cyclic Peptides Really Possess an Entropic Advantage when Binding Proteins? Udugamasooriya G., Spaller‡ M.R.
09:00 00430 Structural Relationships between the Peptidic Antimicrotubule Agents Taltobulin and the Dolastatins Zask‡ A., Kaplan J., Loganzo F., Ayral-Kaloustian S.
09:20 00431 Synthesis and Conformational Analysis of a Pro-Aib Hydroxyethylene Dipeptide Isostere Lama T., Seaman S., Genest N., Lubell W.D.
09:40 Coffee Break
10:00 00432 Synthesis of the Bicyclic Amatoxins and Phallotoxins via Hydroxypyrroloindole Containing Linear Peptides May J.P., Perrin D.M.
10:20 00433 Multivalent and Stereoregular Oligopeptide Polymers to Probe Fertilinb Function in Fertilization Sampson‡ N.S., Lee Y., Lee J., Baessler K., Parker K.A.
11:00 End of Session


REMINDER
11:00 Alfred Bader Award Lecture presented by Mark Lautens in CC-Port Royal C1


Monday PM

BM6CC-Mariner 1

Modern Advances in Protein Engineering

Organizer(s) - Drew Woolley
Chair(s) - Drew Woolley

13:00 00544 Engineering Allosteric Protein Switches Ostermeier‡ M.
13:40 00545 Directed Evolution of Improved Blue and Cyan Fluorescent Proteins with Tyrosine-Derived Chromophores Ai H.-W., Campbell‡ R.E.
14:20 00546 Teaching Proteins New Tricks: From SH2 Domains to Carbon-Phosphorus Lyase Zechel‡ D.L.
15:00 Coffee Break
15:20 00547 Sequence and Structure Based Rational Engineering of Proteins Steipe‡ B.
16:00 00548 Active-Site Engineering of Enzymes to Tailor Specificity Pelletier‡ J.N.
16:40 00549 Evolving the Specificity of Transglutaminase by a Semi-Rational Approach: A New Tool for Peptide Synthesis Chica R.A., Gillet S.M.F.G., Laroche J., Pelletier J.N., Keillor J.W.
17:00 End of Session

BM8CC-Highland 8

NMR of Biological Molecules (Joint with OR and PT) (joint with PT9)

Organizer(s) - David Jakeman
Chair(s) - David Jakeman

13:00 00550 Solution NMR Studies of the Structure and Dynamics of High Molecular Weight Proteins Kay‡ L.E.
13:40 00551 Isotopic Labeling of Ligands and Drugs for Resolving Membrane Receptor Dynamics and Structure at High Resolution Using Solid State NMR Watts‡ A.
14:20 00552 Solid-State 35/37Cl NMR Spectroscopy of Hydrochloride Salts of Amino Acids Implicated in Chloride Ion Transport Channel Selectivity: New Opportunities at 900 MHz Bryce D.L.., Sward G.D., Adiga S.
15:00 Coffee Break
15:20 00553 3D Magic-Angle Spinning Methods and Applications to Structure Determination of Microcrystalline, Fibrous and Membrane Proteins Rienstra‡ C.M., Franks W.T., Wylie B.W., Zhou D.H., Li Y., Frericks H.L., Kloepper K.D., Berthold D.A.
16:00 00554 Direct NMR Detection of the "Invisible" Alkali Metal Ions Bound to DNA G-Quadruplexes Wu‡ G., Ida R., Wong A.
16:40 End of Session


Tuesday AM

BM6CC-Mariner 1

Modern Advances in Protein Engineering

Organizer(s) - Drew Woolley
Chair(s) - Drew Woolley

08:20 00840 Intein-Based Protein Engineering for Structural Biology Iwai‡ H.
09:00 00841 New Chemical Tools for Covalent Protein Modification Francis‡ M.B.
09:40 Coffee Break
10:00 00842 Engineering and Evolution of Enzymes for Glycoside Synthesis: Glycosynthases, Thioglycoligases and Glycosyl Transferases Withers‡ S.G., Warren R.A.J., Aharoni A., Kim Y.-W., Muelleger J., Vaughan M.
10:40 00843 Development of Fluorescent Sensors for the Glycosaminoglycans Nitz‡ M., Sauceda J.
11:20 End of Session


REMINDER
11:25 CIC Medal Lecture presented by Ronald Kluger in CC-Port Royal C1

BM8CC-Highland 8

NMR of Biological Molecules (Joint with OR and PT) (joint with PT9)

Organizer(s) - David Jakeman
Chair(s) - David Jakeman

08:20 00844 STD-NMR/Molecular Modeling Protocol for Probing the Conformations of Ligands Bound to Enzymes Pinto B.M.
09:00 00845 Structural Characterization of Post-Translationally Modified Fusion Associated Small Transmembrane Proteins by NMR Syvitski R., Duncan R., Jakeman D.L.
09:20 00846 How do Dividing Bacteria Find the Middle? Insights from Solution NMR Studies of the Bacterial Cell Division Protein MinE Goto N.K., Ducat T., Ramos D.
09:40 Coffee Break
10:00 00847 Mechanism of Protein Ubiquitination by Human Ubc13-UEV Protein Complexes Spyracopoulos L., Lewis M.J., Hau D.D.
10:20 00848 Structural and Dynamical Basis for the cyclic AMP Signal Transduction in PKA by NMR Das R., Abu-Abed M., Esposito V., Taylor S.S., Melacini G.
10:40 00849 NMR Methods for Studies of Large Proteins and their Application to Problems of Protein Biosynthesis Wagner‡ G., Frueh D., Sun Z.-Y.J., Arthanari H., Moerke N., Reibarkh M., Oberer M., Marintchev A.
11:20 End of Session


REMINDER
11:25 CIC Medal Lecture presented by Ronald Kluger in CC-Port Royal C1


Tuesday PM

BM1CC-Highland 8

Advances in Nucleic Acid Chemistry

Organizer(s) - Dipankar Sen and Yingfu Li
Chair(s) - Yingfu Li

13:40 00957 Understanding RNA Folding Mechanisms Using the Candida Group I Ribozyme as a Model Zhang‡ Y., Xiao M., Zhang L., Jiang Y.-F., Li Z.
14:00 00958 RNA Conformational Dynamics in Riboswitch Function O'Neill‡ M.A.
14:20 00959 A Man-Made Riboswitch Improving Nucleic Acid Enzymes for Functional Genomics Perreault‡ J.P., Brière F.P., Lévesques D., Landry P.
14:40 00960 A General RNA-Capping Ribozyme Retains Stereochemistry during Cap Formation Zaher H.S., Watkins R.A., Unrau‡ P.J.
15:00 Coffee Break
Chair(s) - Dipankar Sen

15:20 00961 The Flexizyme System and its Applications to Ribosomal Synthesis of Nonnatural Biopolymers Suga‡ H.
16:00 00962 RNA-Cleaving Deoxyribozymes with Fluorescence-Signaling Capabilities Li Y., Chiuman W., Shen Y., Kandadai S.A., Brennan J.D.
16:20 00963 Is there a Quantitative and Qualitative Advantage of Using Modified dNTPs for in vitro Selection? Perrin‡ D.M., Ting R., Thomas J.M., Lam C.H., May J.P., Hollenstein M.
16:40 End of Session

BM2CC-Port Royal C1

Carbohydrates and Drug Discovery (Joint with OR) (joint with OR1)

Organizer(s) - Dennis Whitfield
Chair(s) - France-Isabelle Auzanneau

13:40 00964 Characterization of the CS-35 Antibody with Oligosaccharide Fragments of Mycobacterial Lipoarabinomannan Lowary T.L., Kim H.S., Shoemaker G., Klassen J.S., Rademacher C., Peters T., Zheng R.B.
14:00 00965 Expression, Purification and Characterization of a Mycobacterial Galactofuranosyltransferase Lowary T.L., Rose N.L., Completo G.C., Palcic M.M.
14:20 00966 Studies towards more Potent C-Linked Antifreeze Glycoprotein Analogues von Moos E., Trant J., Ben R.N.
14:40 00967 Synthesis and Properties of Model Glycopeptides Containing Glycosylated Hydroxyproline Schweizer F.
15:00 Coffee Break
15:20 00968 A New Strategy for Solid-Phase Synthesis of Carbohydrates Guo‡ Z.
16:00 00969 The Synthesis of Sulfated Carbohydrates Using 2,2,2-Trichloroethoxysulfuryl Imidazolium Salts Ingram L.J., Taylor S.D.
16:20 00970 Synthesis of Sialic Acid Derivatives Modified at the 4-Position Hemeon I., Bennet A.J.
16:40 End of Session

BM4CC-Highland 7

Enzyme Inhibitors and Drug Design

Organizer(s) - Zheng Huang and David Percival
Chair(s) - David Percival

13:40 Introductory Remarks
14:00 00971 Nucleic Acid Metabolism in Staphylococcus aureus: From Target Identification to Isolation and Characterization of Enzyme Inhibitors McKay‡ G.A.
14:40 00972 Strategies for Discovery of Broad Spectrum Inhibitors for Class B (metallo) and Class D (serine) b-Lactamases Johnson J., Evanoff D.P., Heynen M., Goodfellow V., Ramadhar T., Viswanatha T., Taylor N.J., Dmitrienko G.I.
15:00 Coffee Break
Chair(s) - Scott Taylor

15:20 00973 Metal-Based Inhibitors of the Cathepsin Cysteine Proteases Fricker‡ S.P., Mosi R., Baird I.R., Zhu Y., Cameron B.R., Skerlj R.T.
16:00 00974 Use of Enzyme Probes to Define Cellular Selectivity: Application to the Design of Selective Inhibitors of Cathepsin K Black‡ W.C., Bayly C.I., Cromlish W., Desmarais S., Falgueyret J.P., Gauthier J.Y., Lamontagne S., Li C.S., Mellon C., McGrath M., Leger S., Percival M.D.
16:40 End of Session

BM7CC-Mariner 4

Natural Products (Joint with OR) (joint with OR5)

Organizer(s) - Paul Harrison
Chair(s) - Paul Harrison

ISOLATION AND BIOSYNTHESIS

13:40 00975 Biosynthesis of Lovastatin, a Fungal Polyketide and Cholesterol-Lowering Agent Vederas‡ J.C.
14:20 00976 Isolation and Characterization of Novel Jadomycin B Analogues Borissow C.N., Syvitski R.T., Graham C.L., Jakeman D.L.
14:40 00977 Lotifolian: A New Glutathione S-Transferase Inhibiting Triterpenoid from Nauclea latifolia Udenigwe C.C., Ata A., Eze M.O., Uzoegwu P.N.
15:00 Coffee Break
15:20 00978 Development of Biosynthetic Production Methods of Bioactive Marine Terpenes Kerr‡ R.G.
16:00 00979 Stereochemical Control in Antibiotic Polyketide Biosynthetic Enzymes Leadlay‡ P.F.
16:40 End of Session

BMPCC-Port Royal D,E

Posters

Organizer(s) - Stephen Bearne
Chair(s) - Stephen Bearne

From 16:40 until 18:40

See posters in other divisions with which there are joint symposia

16:40 00980 Effects of Myristoylation on the Structure and Stability of the b-Trefoil Protein Hisactophilin Meissner J., Gaspar J.A., Smith M., Meiering E.M.
16:40 00981 Investigations of Purine-Based Nucleoside Bioprobes McLaughlin C.K., Manderville R.A.
16:40 00982 Electronic Properties of Covalently Adducted Purine Nucleosides Sun K.M., McLaughlin C.K., Manderville R.A.
16:40 00983 Synthesis of Bicyclic Cytosine Analogues Wojciechowski F., Wallman A.P., Hudson R.H.E.
16:40 00984 5-Modified Pyrimidines in PNA Wojciechowski F., Hudson R.H.E.
16:40 00985 A Convenient Method for the Preparation of Tetra(dipeptide) Derivatives of Cyclen Wojciechowski F., Hudson R.H.E.
16:40 00986 Fluorniated Olefinic Peptide Nucleic Acids Hollenstein M., Leumann C.J.
16:40 00987 Synthesis and Conformational Analysis of 2'-Fluoro-5-methyl-4'-thioarabinouridine (4'S-FMAU) and Biological Properties of the Corresponding Oligonucleotides Watts J.K., Sadalapure K., Choubdar N., Pinto* B.M., Damha* M.J.
16:40 00988 Synthesis and Characterization of 3'-Thio-2',3'-Dideoxyribonucleotides Isaac S.R., Damha* M.J.
16:40 00989 Synthesis of Fluorescent 5-Alkynyl-2'-deoxyuridines and 2'-Deoxypyrrolocytidines Ghorbani Choghamarani A., Hudson R.H.E.
16:40 00990 Bleomycin: A Potent Small Molecule that Affects Hepatitis C Virus Replication Rakic B., Brulotte M., Pezacki J.P.
16:40 00991 Covalent Schiff Base Catalysis by a DNAzyme AP-Lyase May J.P., Perrin D.M.
16:40 00992 Self Assembly of Adenine and Cyanuric Acid Oligonucleotides into Complex Architectures Palmer A.L., Sleiman H.F.
16:40 00993 DNA Base Functionalization: Synthesis, Self-Assembly and Luminescence of Guanosine Derivatives Martic S., Liu X.Y., Wang S.
16:40 00994 Luminescent Pt(II) Probes of Aptamer Structure Hodgson D.J., Dawson B., Fox-Lee R., DeRosa M.C.
16:40 00995 An ab initio Study of 5-(1-Triazenyl)imidazole, a Simple Structural Analogue of the Antineoplastic Agent Dacarbazine Pye C.C., Doucet K.G., Vaughan K., Glister J.F.
16:40 00996 Synthesis of Allosteric Peptide Mimic Antagonists of the Prostaglandin F2a Receptor Bourguet C.B., Thouin E., Polyak F., Lubell W.D.
16:40 00997 Identification of Two Potent Intermediate Analogue Inhibitors of Mandelate Racemase Bourque J.R., Bearne S.L.
16:40 00998 Discovery of the First Inhibitors of the Cooperative Binding of Human Papillomavirus Type 11 E1 and E2 Proteins Thavonekham B., Yoakim C., White P., Ogilvie W.W., Goudreau N., McGibbon G.A., O'Meara J.A., Naud J., Doyon L., Cordingley M.G., Archambault J.
16:40 00999 Synthesis and in-vitro Cytostatic Activity of Cyclic Curcumin Analogues Nichols C., Harris R., Youssef D., Jha* A., De Clercq E.
16:40 01000 un-24 Incompatibility in Saccharomyces cerevisiae: A Novel Chemotherapeutic Peptide? Smith R.P, Arzhangi Z., Wellman K., Smith M.L.
16:40 01001 Design, Synthesis and in-vitro Anti-Cancer Properties of Amino Acid Conjugates of 3,5-Bisarylmethylene-4-piperidone Maleamic Acids Youssef D., Nichols C., Jha* A., De Clercq E.
16:40 01002 Design and Synthesis of Water-Soluble Analogues of Antineoplastic 3,5-Diarylidene-4-piperidone Derivatives Paul N.K., Jha* A.
16:40 01003 Novel Aminobenzothiazole Nitric Oxide Synthase Inhibitors. Applications in the Treatment of Central Nervous System Disorders Patman J., Garcin-Hosfield E., Renton P., Bhardwaj N., Ramnauth. J., Maddaford S., Rakhit S., Andrews J.S.
16:40 01004 Novel Neuronal Nitric Oxide Synthase (nNOS) Inhibitors in Models of Chronic Pain Patman J., Renton P., Rakhit S., Ramnauth J., Tappia P.S., Aroutiounova N., Vanderah T., Guo W., Porreca F., Maddaford S., Andrews J.S.
16:40 01005 Effect of Huperzine A on Multiple Enzymatic Activities of Butyrylcholinesterase: Implications on the Treatment of Dementias Darvesh S., Walsh R., Martin E.
16:40 01006 The Mechanism of Brønsted Acid Enhanced Decarboxylation of Thiamin-Derived Intermediates Ikeda G., Kluger R.
16:40 01007 Probing Reaction Specificity in Pyridoxal Phosphate Enzymes Farsi A., Aitken S.M.
16:40 01008 Asymmetric Mutagenesis of R67 Dihydrofolate Reductase to Explore the Molecular Basis of Antibiotic Resistance Morley K.L., Schmitzer A.R., Volpato J., Pelletier J.N.
16:40 01009 Probing the Homocysteine-Binding Site of Cystathionine b-Synthase Lodha P., Aitken S.M.
16:40 01010 QM Modeling of the Mechanism of Deamination by Adenosine Deaminase Moussatova A., Ziegler T.
16:40 01011 Cyclization Mechanism of Stilbene Synthase Jiang C., Suh D.-Y.
16:40 01012 An Insight Into bb-Enolase Deficiency: Functional Importance of Amino Acid 376 Zhao S.P., Kornblatt M.J.
16:40 01013 Yeast Model of Human bb-Enolase Deficiency Disease: Characterization of G157D Yeast Enolase Choy B.S.F., Kornblatt M.J.
16:40 01014 Two Novel Single Enzyme Molecule Assays For E. Coli b-Galactosidase Craig D.B., Gavina J.M.A., Nichols E.R.
16:40 01015 GTP-Dependent Activation and Inhibition of E. coli CTP Synthase Lunn F.A., Bearne S.L.
16:40 01016 Explorations of Metal Ion Binding in the Clinically Important Metallo Beta Lactamase IMP-1 Siemann S., Gardonio D., Heynen M., Viswanatha T., Dmitrienko G.I.
16:40 01017 Design of Photo-Switchable SH3 Domain Proteins Zhang F., Lee E., Zarrine-Afsar A., Davidson A.R., Woolley A.
16:40 01018 Designer Reagents: Rational Design of Better Cyclopentanone Monooxygenase (CPMO) Clouthier C.M., Kayser M.M., Reetz M.T.
16:40 01019 Replacement of the Natural Cofactors by Selected Hydrogen Peroxide Donors for CYP3A4 and CYP2D6 Catalysis in Aqueous and Organic Solvents Zhao J., Chefson A., Auclair K.
16:40 01020 siRNA Suppressor Proteins as Chemical Biology Tools Pezacki J.P., Sagan S.M., Koukiekolo R., Goto N.K.
16:40 01021 A Blue-Green Absorbing Cross-Linker for Rapid Photo-Switching of Peptide Helix Content Chi L., Sadovski O., Woolley A.
16:40 01022 Synthesis and Biological Activity of 17b-Estradiol-PEG-Pt(II) Hybrid Compounds Designed for the Treatment of Estrogen Dependent "Female" Cancers Provencher-Mandeville J., Bélanger G., Parent S., Asselin E., Bérubé G.
16:40 01023 Chemotherapy Without Toxic Side Effects! Descôteaux C., Bélanger G., Van Themsche C., Parent S., Asselin E., Bérubé G.
16:40 01024 Synthesis with Improved Yield and Study on Analgesic Effect of 2-Methoxyphencyclidine Ahmadi A., Kassiri M., Fathollahi Y.
16:40 01025 Substituted Terpyridyl Palladium(II) Complexes as Possible Chemotherapeutic Agents: Substitution Kinetics and in vitro Cell Line Screening Corcoran A.M., Haines R.I.
16:40 01026 Preliminary Crystallographic Studies of the Drosophila Toll Receptor Activator Spätzle Yang J., Su Y., Ip T.
16:40 01027 Preliminary SAR Study on Antineoplastic Chalcones Dumas L., Billot X., Bailly S., Gagnon G., St-Denis B., Naranjo S., Steenaart N.A.E., Beauparlant P., Attardo G.
16:40 01028 Simple 4'-Hydroxy-1,1'-biphenyl Derivatives with Potent in vitro Anticancer Activity Branchaud S., Bélec L., Dumas L., Fortin S., Lavallée J.-F., Rioux E., Bailly S., Chang H., Gagnon G., Jang A., Naranjo S., Roulston A., Serfass L., St.-Denis N.S.B., Attardo G.
16:40 01029 Preliminary Study on the Insulinomimetic Activity of Kaempferitrin Isolated from a Taiwan Endemic Plant Cinnamomum osmopheloeum Chen K., Lee M.J., Rao Y.K., Tzeng Y.M.

Wednesday AM

BM1CC-Highland 8

Advances in Nucleic Acid Chemistry

Organizer(s) - Dipankar Sen and Yingfu Li
Chair(s) - Peter Unrau

08:00 01265 DNA: Not Merely the Secret of Life Seeman‡ N.C.
08:40 01266 Nanopatterning Materials Using DNA Sleiman‡ H.F., Aldaye F.
09:00 01267 DNA Polymerization on Gold Nanoparticles via Rolling Circle Amplification: Towards Novel Scaffolds for Three-Dimensional Periodical Nanoassembly Zhao W., Gao Y., Kandadai S.A., Brook M.A., Li Y.
09:20 01268 Applications of M-DNA in Nanoelectronics Lee‡ J.S., Dinsmore M.J., Wettig S.D.
09:40 Coffee Break
Chair(s) - David Perrin

10:00 01269 Site-Specific Incorporation of Reporter Groups for Spectroscopic Studies of Nucleic Acids Sigurdsson‡ S.Th.
10:40 01270 Charge Conduction through Helices as a Structure-Probing Method for DNA and RNA Sen D., Leung E.K., Bergeron L.J.
11:00 01271 Structural Basis for Branch Nucleotide Recognition in the Mammalian Spliceosome MacMillan‡ A.M.
11:20 01272 RNA Recognition by the Vts1p SAM Domain Johnson‡ P.E.
11:40 End of Session

BM4CC-Highland 7

Enzyme Inhibitors and Drug Design

Organizer(s) - Zheng Huang and David Percival
Chair(s) - Zheng Huang

08:00 01273 Applications of Glycosidase Inhibitors from Proteomics to Genetic Diseases Withers‡ S.G., Hekmat O., Rempel B., Reid S., Numao S., Zhang R., Tarling C., Tropak M., Mahuran D., MacDonald J.
08:40 01274 Synthesis of Inhibitors against Aminoglycoside 6'-N-Acetyltransferases (AAC(6')s), an Important Family of Enzymes Causing Antibiotic Resistance Gao F., Auclair K.
09:00 01275 Back to my Roots: Drug Candidates Based on an Herbal Remedy for the Treatment of Type 2 Diabetes. Pinto‡ B.M.
09:40 Coffee Break
Chair(s) - Simon Fricker

10:00 01276 Quinone-Methide Generating Suicide Inhibitors and Reversible Boronic Acid Inhibitors of Steroid Sulfatase Taylor‡ S.D.
10:40 01277 Acyclic Triaryl (Z)-Olefins: Dual Inhibitors of Cyclooxygenases and Lipoxygenases Knaus E., Moreau A., Praveen Rao P.N.
11:00 01278 Discovery and Characterization of Novel Indole-Based Non-Nucleoside Allosteric Inhibitors oOf HCV NS5B Polymerase Gillard J.
11:20 01279 Specifically Targeting the RNase H Activity of HIV-1 RT with Short RNA Hairpins Wahba A.S., Marchand B., Götte M., Damha M.J.
11:40 End of Session


Wednesday PM

BM1CC-Highland 8

Advances in Nucleic Acid Chemistry

Organizer(s) - Dipankar Sen and Yingfu Li
Chair(s) - Chris Wilds

13:00 01380 Fluorescent and Colorimetric DNAzyme and Aptamer Biosensors for a Broad Range of Analytes Lu‡ Y., Liu J.
13:40 01381 Entrapment of Fluorescent Signaling DNA Aptamers in Sol-Gel Derived Silica for the Development of Solid-Phase Enzyme Assays Rupcich N.R., Nutiu R., Li Y., Brennan‡ J.D.
14:00 01382 DNA Bulge Recognition and DNA Slippage: Lessons Learned from Nature Xi‡ Z.
14:20 01383 Nucleobase Discriminating Fluorophores Hudson‡ R.H.E.
14:40 01384 In Vivo Tracking of RNA via Functional Group Labeling Noestheden M., Hu Q., Evans C., Pezacki J.P.
15:00 Coffee Break
Chair(s) - Yingfu Li

15:20 01385 Efficient and Persistent Gene Silencing by Arabinonucleic Acids Damha‡ M.J.
16:00 01386 Synthesis and Investigation in Interstrand Cross-Linked DNA Wilds‡ C.J., Noronha A.M., Booth J.D., Palus E.
16:20 01387 Aminopyridine Peptide Nucleic Acids for Molecular Recognition of Quadruplex DNA Linkletter B.A., Gill M.A., McInnis M., Breining B.
16:40 01388 Inhibition of Ribozymes and DNA Enzymes by DNA Intercalators Hollenstein M., Perrin D.M.
17:00 End of Session

BM2CC-CornwallisSuite

Carbohydrates and Drug Discovery (Joint with OR) (joint with OR1)

Organizer(s) - Dennis Whitfield
Chair(s) - Robert Ben


REMINDER
13:00 Boehringer Ingelheim Award Lecture presented by Jason Kennedy in CC-Highland 7

13:40 01389 Characterizing Protein-Carbohydrate Interactions Using NanoES and FT-ICR/MS Klassen‡ J.S., Kitova E.N.
14:20 01390 Glycorandomization of Jadomycin B: A Chemo-Enzymatic Approach Timmons S.C., Jakeman D.L.
14:40 01391 New Effective Glycosylation Strategy at O-4 of N-Acetyl Glucosamine Glycosyl Acceptors Cheng A., Colangelo K., Bonin M., Liao L., Hendel J., Auzanneau F.-I.
15:00 Coffee Break
15:20 01392 Development and Biological Application of b-N-Acetylglucosamindase Inhbitors Macauley M.S., Whitworth G.E., Stubbs K.A., Debowski A., Chin D., Vocadlo‡ D.J.
16:00 01393 Design and Synthesis of New Bicyclic Mechanistic Probes for the UDP-Galactopyranose Mutase Sadeghi-Khomami A., Forcada T.J., Jones V.C., McNeil M.R., Thomas N.R.
16:20 01394 Component Analysis of the X-C-Y Anomeric Effect (X = O, S; Y = F, OMe, NHMe) by DFT Molecular Orbital Calculations and Natural Bond Orbital Analysis Watts J.K., Trapp M.L., Weinberg N., Pinto B.M.
16:40 01395 Do b-D-Glycopyranosides Ionize via the B3,O Conformation? Whitfield D.M.
17:00 End of Session

BM7CC-Mariner 4

Natural Products (Joint with OR) (joint with OR5)

Organizer(s) - Paul Harrison
Chair(s) - John Vederas


REMINDER
13:00 Boehringer Ingelheim Award Lecture presented by Jason Kennedy in CC-Highland 7

SYNTHESIS AND METABOLISM

13:40 01396 A Concise Total Synthesis of Bullatacin Pagenkopf‡ B.L.
14:20 01397 First Asymmetric Total Synthesis of Allosecurinine Wanner K.T., Gebauer P.
14:40 01398 Formal Enantioselective Synthesis of (+)-Compactin Robichaud J., Tremblay F.
15:00 Coffee Break
15:20 01399 An Efficient Synthesis of the Diazobenzo[a]fluorene Ring System of the Antitumour Antibiotic Isoprekinamycin Liu W., Buck M., Shang M., Taylor N.J., Dmitrienko G.I.
15:40 01400 Total Synthesis of Phenanthroindolizidine and Phenanthroquinolizidine Alkaloids via Platinum-Catalysed Cycloisomerization Kennedy J.W.J., Fürstner A.
16:00 01401 Studies Directed Towards the Synthesis of Reiswigin A: Total Synthesis of epi-Reiswigin A and (-)-Reiswigin A MaGee D.I., Shannon D.E., Setiadji S.
16:20 01402 Phytoalexin Metabolism: Boosting Chemical Defenses in Crucifer Plants Pedras‡ M.S.C., Jha M., Okeola O.G., Hossain M., Suchy M., Gadagi R.
17:00 End of Session

BM10DH-Baronet 1,2,3

General

Organizer(s) - Stephen Bearne
Chair(s) - Stephen Bearne

13:00 01403 Bi-Aromatic Compounds that Modulate Folding and Self-Assembly of the Alzheimer Peptide, b-Amyloid Carter M.D., Weaver D.F
13:20 01404 Chemistry and Biology of Avrainvillamide and Stephacidin B Wulff J.E., Myers A.G.
13:40 01405 Rhodotorula glutinis Phenylalanine Ammonia Lyase: GC-MS Determination of Reversal Reaction Product, Storage Stabilization, Induction, and Inhibition D'Cunha G.B., Wall M.J.
14:00 01406 Application of Lipoxygenase to Degrade Wood Extractives in Thermomechanical Pulp Zhang X., Nguyen D., Paice M., Tsang A., Renaud S.
14:20 01407 A Collaborative Health Research Project: Characterization of Rat Scar Tissue by Synchrotron FTIR and Conventional Immunohistochemistry Wiens R.A., Rak M., Abraham S., Cox N., Schultke E., Juurlink B.H.J., Kulyk W., Gough K.M.
14:40 01408 Starting a New Company: Business Plan, Road Show Presentation and Funding Challenges for the Founding Scientist Skinner J.D.
15:00 End of Session


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